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beta2-Microglobulin, B2M Protein (Active)
beta2-Microglobulin, B2M Protein (Active)
- 中文名称：
- beta2-Microglobulin, B2M Protein (Active)
- 英文名称：
- beta2-Microglobulin, B2M Protein (Active)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA59064
- 规格：
- 0.1 mg|1 mg|2x1 mg|3x1 mg|4x1 mg
- 保存建议：
- Upon receipt, aliquot and store at -20 degree C or -80 degree C for long term.
Avoid repeated freeze and thaw cycles.
- 货期：
- 6-8周
- 纯度：
- >90% by SDS-PAGE
- 产品形式：
- Liquid; Each vial contains 10 mM PBS (pH 7.4).
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Purified human beta2-Microglobulin protein.
Background: Beta-2-microglobulin (B2M) is a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. B2M gene contains 4 exons and spans approximately 8 kb. The neonatal Fc receptor (FcRn) is a heterodimer of a nonclassical MHC class I alpha and B2M that binds the 2 most abundant serum proteins, IgG and albumin, after their constitutive cellular uptake. FcRn binds both proteins, thus acting as a salvage pathway, protecting them from lysosomal degradation and extending the catabolic half-lives of both proteins. Beta-2-microglobulin had been found in the serum of normal individuals and in the urine in elevated amounts in patients with Wilson disease, cadmium poisoning, and other conditions leading to renal tubular dysfunction.
