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phospho-beta-Tubulin (Ser-172) Peptide
phospho-beta-Tubulin (Ser-172) Peptide
- 中文名称：
- phospho-beta-Tubulin (Ser-172) Peptide
- 英文名称：
- phospho-beta-Tubulin (Ser-172) Peptide
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA71540
- 规格：
- 0.05 mg|2x0.05 mg|3x0.05 mg|5x0.05 mg|4x0.05 mg
- 保存建议：
- Store at -20 degree C. Stable for 1 year.
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Blocking Peptide is supplied in 50ul phosphate-buffered saline and 0.05% sodium azide.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Microtubules (MTs) are cytoskeletal elements that play an essential role in cell division and cytoplasmic organization. MTs are dynamic polymers of alpha / beta-tubulin heterodimers. At least two populations of MTs, called dynamic and stable according to their rates of turnover, are readily distinguishable in cells. The proteins associated with MTs (MAPs) are among the best-known factors that regulate MT dynamics and stability. In addition, a variety of different post-translational modifications may also regulate MT dynamics and stability. Phosphorylation is one of these modifications and it can occur on serine, threonine, and tyrosine residues in b-tubulin isoforms. Multiple kinases can phosphorylate Ser-444 at the C-terminus of beta-III-tubulin in vitro. Unphosphorylated Ser-444 in beta-III-tubulin is an early marker for cells of neuronal lineage, while phosphorylation of Ser-444 is upregulated after neuronal maturation and may preferentially occur in assembled MTs. By contrast, Cdk1 phosphorylation of Ser-172 in beta-tubulin occurs in mitotic cells and may impair tubulin incorporation into microtubules.
