-
2019-nCoV Spike protein S1 (P681H)
2019-nCoV Spike protein S1 (P681H)
- 中文名称：
- 2019-nCoV Spike protein S1 (P681H)
- 英文名称：
- 2019-nCoV Spike protein S1 (P681H)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA73331
- 规格：
- 0.01 mg|0.02 mg|0.05 mg|0.1 mg|2x0.1 mg
- 保存建议：
- Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Recombinant protein stored in 50mM sodium phosphate, pH7.5, 300mM NaCl, 150mM imidazole.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Recombinant 2019-nCoV Spike protein S1 (P681H)(16-685) was expressed in CHO cells using a C-terminal His-tag. The gene accession number is MN908947.
Novel coronavirus SARS-CoV-2 has caused the pandemic of the respiratory diseases (COVID-19) around the world in 2020 (1). The spike glycoprotein (S) of coronavirus, a type I transmembrane protein containing two subunits, S1 and S2 is known to bind with host cells through the interaction with angiotensin-converting enzyme 2 (ACE2)(2). Upon binding of S1subunit of Spike protein to the host ACE2, TMPRSS2 cleaves at the S1/S2 boundary or within S2 subunit to facilitate the entry of viral genomes into the host cells. Of the 14 defined mutations in the UK variant of SARS-CoV-2, also known as VUI-2020/01 or lineage B.1.1.7, P618H mutation in the Spike protein is found adjacent to the furin cleavage site rendering it more suitable for hydrolysis by TMPRSS2 and augmenting the viral fusion (3).
上一篇：2019-nCoV Spike protein S1 (K417N, E484K, N501Y, D614G)
下一篇：2019-nCoV Spike protein S1 (T95I, Y144T, Y145S, ins146N, R346K, E484K, N501Y, D614G, P681H)
