-
Cas13a (LwC2c2), Active
Cas13a (LwC2c2), Active
- 中文名称：
- Cas13a (LwC2c2), Active
- 英文名称：
- Cas13a (LwC2c2), Active
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA73387
- 规格：
- 0.05 mg|0.1 mg|0.25 mg|1 mg|2x1 mg
- 保存建议：
- Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- Recombinant protein stored in 50mM sodium phosphate, pH8.0, 300mM NaCl, 150mM imidazole, 1mM DTT, 10% glycerol.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Recombinant Leptotrichia wadei Cas13a (LwC2c2)(1-1152) was expressed in E Coli with a C-terminal His tag. The protein accession number is WP_021746774.
Cas13a is RNA-guided RNA endonuclease that belongs to class 2 type VI CRISPR-Cas system (1). Cas13a possess both RNA recognition and cleavage activities and cleaves RNA through conserved basic residues within its two HEPN domains (2). Interestingly, activated Cas13a induces collateral cleavage of nearby non-targeted RNAs in a nonspecific manner. This property of Cas13a enzyme has been leveraged for the development of sensitive and robust nucleic acid detection test tool for clinical samples. tests using Cas13a for detection of SARS-CoV-2 offers promising alternative to quantitative PCR (3). In addition, CRISPR-Cas13a system provides opportunity for the development of clinical research in precision oncology (4).
