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Human glucocorticoid receptor-alpha ELISA Kit
Human glucocorticoid receptor-alpha ELISA Kit
- 中文名称：
- Human glucocorticoid receptor-alpha ELISA Kit
- 英文名称：
- Human glucocorticoid receptor-alpha ELISA Kit
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA16013
- 规格：
- 48-Strip-Wells|96-Strip-Wells|2x96-Strip-Wells|3x96-Strip-Wells|4x96-Strip-Wells
- 保存建议：
- 将所有试剂储存在2-8摄氏度
- 货期：
- 6-8周
- 检测种属：
- Human
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Intended Uses: This GRS ELISA kit is to be used for the determination of Glycyl-tRNA synthetase (GRS) in human serum and cell lysate. This kits is intended for research use only!!Background/Introduction: GRS ELISA kit applies a technique called sandwich immunoassay. The microtiter plate provided in this kit has been pre-coated with a monoclonal antibody fragments specific for GRS. This GRS ELISA kit is to be used for the determination of GRS in human serum and cell lysate. As ancient proteins that arose as part of the development of the genetic code, aminoacyl-tRNA synthetases (ARSs) are essential components of the translation apparatus. The 20 enzymes, 1 for each amino acid, catalyze the attachment of each amino acid to its cognate tRNA in the cytoplasm, where the charged tRNAs are then used for ribosomal protein synthesis(1). Glycyl-tRNA synthetase (GRS) autoantibodies were detected in serum of subjects with cancer(2). In part because of our ongoing investigations of its novel functions, we focused on GRS. GRS can be secreted from macrophages in response to Fas ligand that is released from tumor cells. Through cadherin (CDH)6 (K-cadherin), GRS bound to different ERK-activated tumor cells, and released phosphatase 2A (PP2A) from CDH6. The activated PP2A then suppressed ERK signaling through dephosphorylation of ERK and induced apoptosis.With in vivo administration of GRS, growth of tumors with a high level of CDH6 and ERK activation were strongly suppressed. These observations led us to attempt to understand a potential role for GRS as a secreted protein in a cancer microenvironment (3).
