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Recombinant Human Heparanase-1 Active
Recombinant Human Heparanase-1 Active
- 中文名称：
- Recombinant Human Heparanase-1 Active
- 英文名称：
- Recombinant Human Heparanase-1 Active
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA10906
- 规格：
- 0.001 mg|0.004 mg|0.016 mg|2x0.016 mg|3x0.016 mg
- 保存建议：
- Store at-80°C.
- 货期：
- 6-8周
- 纯度：
- > 95% on SDS-PAGE (Fig. 1, B)
> 95% on RP-HPLC (Fig. 1, C)
- 产品形式：
- 20 mM Acetate buffer; 750 mM NaCl; pH 5.4 per 1 µg of rhHPA1
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Background: Heparanase is an endo beta-D-glucuronidase, which degrades heparan sulfate side chains of heparan sulfate proteoglycans (HSPGs) in the extracellular matrix. Heparanase plays an important role in ECM degradation, facilitating the migration and extravasation of tumor cells and inflammatory leukocytes (1, 2, 3). Upon degradation, heparanase releases growth factors and cytokines that stimulate cell proliferation and chemotaxis (4, 5). Heparanase is a heterodimer comprised of a 50 kDa subunit harboring the active site and a 8 kDa subunit. It is produced as a latent 65 kDa precursor and proteolytically processed to its active form (1, 6). Heparanase is highly expressed in myeloid leukocytes (i.e. neutrophils) in platelets and in human placenta. Human heparanase was found to be upregulated in various types of primary tumors, correlating in some cases with increased tumor invasiveness and vascularity and with poor prospective survival (7, 8).
