-
6,6'-Trehalose Dimycolate (Cord-Factor, TDM)
6,6'-Trehalose Dimycolate (Cord-Factor, TDM)
- 中文名称：
- 6,6'-Trehalose Dimycolate (Cord-Factor, TDM)
- 英文名称：
- 6,6'-Trehalose Dimycolate (Cord-Factor, TDM)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA14806
- 规格：
- 1 mg|5 mg|10 mg|2x10 mg|3x10 mg
- 保存建议：
- Store at -20 degree C in the dark. Stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
- 货期：
- 6-8周
- 纯度：
- Purified by Thin layer chromatography. >97%. Single spot
- 产品形式：
- Supplied as a lyophilized powder
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
6,6'-Trehalose Dimycolate (Cord Factor, source: Mycobacterium bovis, Bacillus Calmette Guerin) 6,6'-dimycoloyl-a-D-trehalose (Mycobacterium bovis, BCG) is used as an immunoadjuvant for the induction and non-specific stimulation of antibody production against unrelated antigens. This results in an increased host resistance against infections and cancer, in the potentiation of vaccine immunogeneticity and in an increase of DNA vaccination efficacy.
6'6-Trehalose dimycolate (TDM) exhibits strong immunomodulatory effects, greatly enhancing the efficacy of DNA vaccination, shown to facilitate single-shot prime-boost DNA vaccines (3). TDM from M. bovis has a lower granulomatogenic activity as compared to TDM from M. tuberculosis (5). Preinjection of TDM followed by antigen injection triggers elevated antibody production (2). TDM stimulates macrophages, enhances non-specific immune responses and stimulates the antigen-presenting ability (7, 10). TDM Exhibits anti-tumor activity (2). TDM induces the production of both Th1-type and Th2-type cytokines (IFN-alpha, IFN-beta, IFN-gamma, IL-4, IL-6, IL-10, IL-12, TNF-alpha) as well as chemokines (MCP-1, MIP-1alpha, IL-8) (4, 6, 8, 9,11). TDM upregulates MHC class II expression on macrophages and causes expansion of Th1 cells (9). TDM is non-toxic on organisms and serves as protection against killing from macrophages. TDM becomes antigenic and highly toxic, when exposed to lipid surfaces.
