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MDA5/NF-kB Leeporter Luciferase Reporter-HEK293T Cell Line
MDA5/NF-kB Leeporter Luciferase Reporter-HEK293T Cell Line
- 中文名称：
- MDA5/NF-kB Leeporter Luciferase Reporter-HEK293T Cell Line
- 英文名称：
- MDA5/NF-kB Leeporter Luciferase Reporter-HEK293T Cell Line
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA14874
- 规格：
- 1 Vial|2x1 Vial|3x1 Vial|4x1 Vial|5x1 Vial
- 保存建议：
- Immediately upon receipt, store in liquid nitrogen.
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- N/A
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
The MDA5 Leeporter™ Luciferase Reporter cell line is a stably transfected HEK 293T cell line which expresses human melanoma differentiation-associated protein-5 (MDA5) and Renilla luciferase reporter gene under the transcriptional control of an NF-kB response element. As a dsRNA helicase enzyme, MDA5 is encoded by the IFIH1 gene. MDA5 is one of the RIG-I-like receptors (RLRs) that are a family of DExD/H box RNA helicases including MDA5, RIG-I and LPG2, which play a major role in pathogen sensing of RNA virus infection to initiate and modulate antiviral immunity. RLR expression is typically maintained at low levels in resting cells but is greatly increased during inflammation, specifically with IFN exposure and after virus infection. MDA5 detects cytoplasmic dsRNA generated during viral replication unlike Toll-like receptor 3 (TLR3) which can detect phagocytosed dsRNA in endosomes. MDA5 also responds to poly(I:C), the synthetic analog of viral dsRNA. The MDA5 activation by poly(I:C) is shown in Figure 1.
