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alpha-Conotoxin ImI (trifluoroacetate salt)
alpha-Conotoxin ImI (trifluoroacetate salt)
- 中文名称：
- alpha-Conotoxin ImI (trifluoroacetate salt)
- 英文名称：
- alpha-Conotoxin ImI (trifluoroacetate salt)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA227022
- 规格：
- INQUIRE
- 保存建议：
- 粉末:-20摄氏度存放3年< br >在溶剂中:-80摄氏度存放2年
- 货期：
- 6-8周
- 纯度：
- 98%
- 产品形式：
- N/A
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
alpha-Conotoxin ImI is a conotoxin that has been found inC. imperialisand has receptor antagonist and anticancer activities.1It is a peptide antagonist of homomeric alpha7 nicotinic acetylcholine receptors (nAChRs; IC50= 220 nM). alpha-Conotoxin ImI is selective for alpha7 nAChRs over alpha2beta2, alpha3beta2, alpha4beta2, alpha2beta4, alpha3beta4, alpha4beta4, and alpha1beta1gammadelta subunit-containing nAChRs at 5 uM but does inhibit homomeric alpha9 nAChRs (IC50= 1,800 nM). Administration of paclitaxel in micelles containing alpha-conotoxin ImI decreases tumor growth in an MCF-7 mouse xenograft model.2Intracerebroventricular, but not intraperitoneal, administration of alpha-conotoxin ImI (20 nmol/animal) induces seizures in rats.3
