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Cyclic di-IMP (sodium salt)
Cyclic di-IMP (sodium salt)
- 中文名称：
- Cyclic di-IMP (sodium salt)
- 英文名称：
- Cyclic di-IMP (sodium salt)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA227248
- 规格：
- INQUIRE
- 保存建议：
- 粉末:-20摄氏度存放3年< br >在溶剂中:-80摄氏度存放2年
- 货期：
- 6-8周
- 纯度：
- 98%
- 产品形式：
- N/A
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Cyclic di-IMP (sodium salt)(c-di-IMP) is a synthetic second messenger structurally related to the bacterial second messengers cyclic di-GMP and cyclic di-AMP. C-di-IMP has adjuvant properties when co-administered with antigens in vitro and by mucosal routes in vivo. C-di-IMP enriches the population of MHC class I and II, CD80, CD86, CD40, and CD54 positive dendritic cells derived from murine bone marrow. It also stimulates macrophages at 500 ng/ml. Mice immunized with beta-galactosidase (beta-gal) plus c-di-IMP through the intranasal route show a humoral immune response, evidenced by an increase in IgG titers up to 2-fold compared to mice immunized with beta-gal alone. Mice immunized with beta-gal plus c-di-IMP also exhibit a Th1/Th2 response, indicating that the adjuvant activity of c-di-IMP leads to a cellular immune response as well.
