-
Tenofovir diphosphate (sodium salt)
Tenofovir diphosphate (sodium salt)
- 中文名称：
- Tenofovir diphosphate (sodium salt)
- 英文名称：
- Tenofovir diphosphate (sodium salt)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA227308
- 规格：
- INQUIRE
- 保存建议：
- 粉末:-20摄氏度存放3年< br >在溶剂中:-80摄氏度存放2年
- 货期：
- 6-8周
- 纯度：
- 98%
- 产品形式：
- N/A
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Tenofovir diphosphate is an inhibitor of HIV reverse transcriptase (Kis = 0.022 and 1.55 uM for RNA and DNA, respectively) and hepatitis B virus (HBV) polymerase (Ki = 0.18 uM). It is selective for these enzymes over DNA polymerase alpha and beta, as well as mitochondrial DNA polymerase gamma (Kis = 5.2, 81.7, and 59.5 uM, respectively). Tenofovir diphosphate is formed intracellularly through phosphorylation of the prodrugs tenofovir and tenofovir disoproxil by nucleotide kinases. Increased levels of tenofovir diphosphate in isolated peripheral blood mononuclear cells (PBMCs) correlate with a decrease in the risk of simian HIV (SHIV) acquisition in a macaque model of rectal SHIV transmission.
