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beta-Endorphin (1-27)(human)(trifluoroacetate salt)
beta-Endorphin (1-27)(human)(trifluoroacetate salt)
- 中文名称：
- beta-Endorphin (1-27)(human)(trifluoroacetate salt)
- 英文名称：
- beta-Endorphin (1-27)(human)(trifluoroacetate salt)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA227392
- 规格：
- INQUIRE
- 保存建议：
- 粉末:-20摄氏度存放3年< br >在溶剂中:-80摄氏度存放2年
- 货期：
- 6-8周
- 纯度：
- 98%
- 产品形式：
- N/A
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
beta-Endorphin (1-27) is an endogenous peptide that binds to u-, delta-, and kappa-opioid receptors (Kis = 5.31, 6.17, and 39.82 nM, respectively, in COS-1 cells expressing rat receptors). It binds to rat and mouse brain membrane preparations (IC50s = 1.1 and 5.7 nM, respectively) and induces chemotaxis of human monocytes in vitro when used at a concentration of 1 nM. Intracerebroventricular administration of beta-endorphin (1-27) increases the latency to tail withdrawal in response to thermal stimulation in mice with a median antinociceptive dose (AD50) of 1,500 pmol per animal. It inhibits antinociception induced by beta-endorphin in mice in response to thermal stimuli when administered at a dose of 65 pmol per animal. In rats, beta-endorphin (1-27) does not affect drug-associated place preference when administered at doses up to 20 ug, i.c.v., but inhibits beta-endorphin-induced place preference when administered at a dose of 10 ug per animal.
