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Recombinant Rat Transforming growth factor beta-1 (Tgfb1), partial
Recombinant Rat Transforming growth factor beta-1 (Tgfb1), partial
- 中文名称：
- Recombinant Rat Transforming growth factor beta-1 (Tgfb1), partial
- 英文名称：
- Recombinant Rat Transforming growth factor beta-1 (Tgfb1), partial
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA233517
- 规格：
- 0.02 mg (E-Coli)|0.1 mg (E-Coli)|1 mg (E-Coli)|5x1 mg (E-Coli)|
- 保存建议：
- 在-20摄氏度下储存。对于长期储存，在-20摄氏度或-80摄氏度下储存。在4摄氏度下储存工作等分试样最多一周。不建议反复冻融。
- 货期：
- 6-8周
- 纯度：
- Greater or equal to 85% purity as determined by SDS-PAGE.
- 产品形式：
- Lyophilized or liquid (Format to be determined during the manufacturing process)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane proteolysis (RIP). Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells. Mediates SMAD2/3 activation by inducing its phosphorylation and subsequent translocation to the nucleus. Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types
