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Recombinant Escherichia coli Probable phosphatidylethanolamine transferase Mcr-1 (mcr1), partial
Recombinant Escherichia coli Probable phosphatidylethanolamine transferase Mcr-1 (mcr1), partial
- 中文名称：
- Recombinant Escherichia coli Probable phosphatidylethanolamine transferase Mcr-1 (mcr1), partial
- 英文名称：
- Recombinant Escherichia coli Probable phosphatidylethanolamine transferase Mcr-1 (mcr1), partial
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA233574
- 规格：
- 0.02 mg (E-Coli)|0.1 mg (E-Coli)|1 mg (E-Coli)|5x1 mg (E-Coli)|
- 保存建议：
- 在-20摄氏度下储存。对于长期储存，在-20摄氏度或-80摄氏度下储存。在4摄氏度下储存工作等分试样最多一周。不建议反复冻融。
- 货期：
- 6-8周
- 纯度：
- Greater or equal to 85% purity as determined by SDS-PAGE.
- 产品形式：
- Lyophilized or liquid (Format to be determined during the manufacturing process)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Probably catalyzes the addition of a phosphoethanolamine moiety to lipid A. Phosphoethanolamine modification of lipid A gives polymyxin resistance (PubMed:26603172).1 Publication
Confers resistance to polymyxin-type antibiotics; expression of the Mcr-2 prin in E.coli increases colistin and polymyxin B minimal inhibitory concentration (MIC) from 0.5 mg/ml to 2.0 mg/ml. The pHNSHP45 plasmid can transfer efficiently (0.1 to 0.001) to other E.coli strains by conjugation and increases polymxin MIC by 8- to 16-fold; it may not require selective pressure to be maintained in the cell. When transformed into K.pneumoniae or P.aeruginosa it also increases polymxin MIC 8- to 16-fold. In a murine (BALB/c mice) thigh infection study using an mcr1-encoding plasmid isolated from a human patient, the plasmid confers in vivo protection against colistin (PubMed:26603172).
