-
Recombinant Human Platelet glycoprotein Ib beta chain (GP1BB), partial
Recombinant Human Platelet glycoprotein Ib beta chain (GP1BB), partial
- 中文名称：
- Recombinant Human Platelet glycoprotein Ib beta chain (GP1BB), partial
- 英文名称：
- Recombinant Human Platelet glycoprotein Ib beta chain (GP1BB), partial
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA235242
- 规格：
- 0.02 mg (E-Coli)|0.02 mg (Baculovirus)|0.1 mg (E-Coli)|0.1 mg (Baculovirus)|1 mg (E-Coli)
- 保存建议：
- 在-20摄氏度下储存。对于长期储存，在-20摄氏度或-80摄氏度下储存。在4摄氏度下储存工作等分试样最多一周。不建议反复冻融。
- 货期：
- 6-8周
- 纯度：
- Greater or equal to 85% purity as determined by SDS-PAGE.
- 产品形式：
- Lyophilized or liquid (Format to be determined during the manufacturing process)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. Mutations in the GPIb beta subunit have been associated with Bernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. The 206 amino acid precursor of GPIb beta is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes. A 411 amino acid protein arising from a longer, unspliced transcript in endothelial cells has been described; however, the authenticity of this product has been questioned. Yet another less abundant GPIb beta mRNA species of 3.5 kb, expressed in nonhematopoietic tissues such as endothelium, brain and heart, was shown to result from inefficient usage of a non-consensus polyA signal within a separate gene (septin 5) located upstream of this gene. In the absence of polyadenylation from its own imperfect site, the septin 5 gene uses the consensus polyA signal of this gene.
