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Recombinant Human NACHT, LRR and PYD Domains-Containing Protein 3 (NLRP3), Partial
Recombinant Human NACHT, LRR and PYD Domains-Containing Protein 3 (NLRP3), Partial
- 中文名称：
- Recombinant Human NACHT, LRR and PYD Domains-Containing Protein 3 (NLRP3), Partial
- 英文名称：
- Recombinant Human NACHT, LRR and PYD Domains-Containing Protein 3 (NLRP3), Partial
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA235628
- 规格：
- 0.02 mg (Yeast)|0.1 mg (Yeast)|1 mg (Yeast)|5x1 mg (Yeast)|
- 保存建议：
- The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 degree C/-80 degree C. The shelf life of lyophilized form is 12 months at -20 degree C/-80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
- 货期：
- 6-8周
- 纯度：
- Greater or equal to 85% purity as determined by SDS-PAGE.
- 产品形式：
- Lyophilized or liquid (Format to be determined during the manufacturing process)
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
As the sensor component of the NLRP3 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP3, PYCARD and CASP1 (and possibly CASP4 and CASP5). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP3 inflammasome is also required for HMGB1 secretion. The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death. Under resting conditions, NLRP3 is autoinhibited. NLRP3 activation stimuli include extracellular ATP, reactive oxygen species, K+ efflux, crystals of monosodium urate or cholesterol, amyloid-beta fibers, environmental or industrial particles and nanoparticles, cytosolic dsRNA, etc. However, it is unclear what constitutes the direct NLRP3 activator. Activation in presence of cytosolic dsRNA is mediated by DHX33. Independently of inflammasome activation, regulates the differentiation of T helper 2 (Th2) cells and has a role in Th2 cell-dependent asthma and tumor growth. During Th2 differentiation, required for optimal IRF4 binding to IL4 promoter and for IRF4-dependent IL4 transcription. Binds to the consensus DNA sequence 5'-GRRGGNRGAG-3'. May also participate in the transcription of IL5, IL13, GATA3, CCR3, CCR4 and MAF.
