-
IDO1 Antibody
IDO1 Antibody
- 中文名称：
- IDO1 Antibody
- 英文名称：
- IDO1 Antibody
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA243839
- 规格：
- 0.05 mL|0.1 mL|2x0.1 mL|3x0.1 mL|4x0.1 mL
- 保存建议：
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
- 货期：
- 6-8周
- 纯度：
- Affinity-chromatography
- 产品形式：
- Liquid. Rabbit IgG in phosphate buffered saline, PH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses (PubMed:25691885). Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells (PubMed:25691885). Acts as a suppressor of anti-tumor immunity (PubMed:23103127, PubMed:25157255, PubMed:14502282, PubMed:25691885). Limits the growth of intracellular pathogens by depriving tryptophan (PubMed:25691885). Protects the fetus from maternal immune rejection (PubMed:25691885).
Description: IDO1 is a heme enzyme that catalyzes the oxidation of L-tryptophan (L-Trp) into kynurenine metabolites, the buildup of which causes T-cell suppression and allows tumor cells to evade immune system monitoring and clearance. In vitro, IDO1 has been demonstrated to block T cell activation and promote the formation of T regulatory cells. In vivo, IDO1 is well known for facilitating tumor immune evasion through its immunoregulatory role. IDO1 is significantly expressed in a number of malignancies, including colorectal cancer, breast cancer, and esophageal carcinoma, and its overexpression has been linked to a bad prognosis in various cancers.
Genes for IDO1 antibody's heavy and light chains were cloned into plasma vectors, which were subsequently transfected into mammalian cells for expression. The resulting product is the recombinant IDO1 antibody. This recombinant IDO1 antibody was subsequently purified from the culture medium of transfected host cell lines through A synthesized peptide derived from human INDO. It has verified to detect IDO1 protein Human in the ELISA, IHC.
