-
GBA Antibody
GBA Antibody
- 中文名称：
- GBA Antibody
- 英文名称：
- GBA Antibody
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA243967
- 规格：
- 0.05 mL|0.1 mL|2x0.1 mL|3x0.1 mL|4x0.1 mL
- 保存建议：
- 收到后，储存在-20摄氏度或-80摄氏度。避免反复冷冻。
- 货期：
- 6-8周
- 纯度：
- Affinity-chromatography
- 产品形式：
- Liquid. Rabbit IgG in phosphate buffered saline, PH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Relevance: extracellular exosome, lysosomal lumen, lysosomal membrane, glucosylceramidase activity, receptor binding, cellular response to tumor necrosis factor, ceramide biosynthetic process, glucosylceramide catabolic process, glycosphingolipid metabolic process, negative regulation of inflammatory response
Description: GBA encodes the glucocerebrosidase (GCase), a lysosomal glycoside hydrolase that catalyzes the hydrolysis of the glycolipid glucosylceramide (GlcCer) to glucose and ceramide. It is involved in the metabolism of sphingolipids. GBA deficiency results in the buildup of GlcCer and disruption of lipid balance. Gaucher's disease has been linked to human GBA gene mutations, which are numerically the most important risk factor for developing Parkinson's disease (PD), accounting for at least 5% of all PD cases. Furthermore, sporadic PD brains show a decrease in GBA activity.
The recombinant GBA antibody was generated in vitro through inserting cloned GBA genes into expression vectors. The expression vector was then inserted into a mammalian cell to express this GBA antibody. It has been validated in ELISA, WB. Every step in the production was controlled strictly.
