-
Human Recombinant Truncated Tau (AA297-391)(dGAE C322A) Protein Pre-formed Fibrils
Human Recombinant Truncated Tau (AA297-391)(dGAE C322A) Protein Pre-formed Fibrils
- 中文名称：
- Human Recombinant Truncated Tau (AA297-391)(dGAE C322A) Protein Pre-formed Fibrils
- 英文名称：
- Human Recombinant Truncated Tau (AA297-391)(dGAE C322A) Protein Pre-formed Fibrils
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA254092
- 规格：
- 0.1 mg|2x0.1 mg|5x0.1 mg
- 保存建议：
- Store at -80 degree C
- 货期：
- 6-8周
- 纯度：
- >95%; Ion-exchange Purified
- 产品形式：
- PBS pH 7.4
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Alzheimer's Disease (AD) is the most common neurodegenerative disease, affecting 10% of seniors over the age of 65 (1). It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing paired helical filaments (PHFs). A truncated 95-amino acid fragment corresponding to residues 297-391 of full-length tau has been shown to assemble into PHF-like fibrils in vitro in the absence of additives or templates (3). This fragment has been found in the core of PHFs from AD brains and forms filaments that closely resemble PHFs isolated from AD brains (3). The C322A mutation leads to enhanced self-assembly into long and ordered PHFs (3).
