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Human Recombinant Superoxide dismutase Protein Pre-formed Fibrils
Human Recombinant Superoxide dismutase Protein Pre-formed Fibrils
- 中文名称：
- Human Recombinant Superoxide dismutase Protein Pre-formed Fibrils
- 英文名称：
- Human Recombinant Superoxide dismutase Protein Pre-formed Fibrils
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA254095
- 规格：
- 0.1 mg|2x0.1 mg|5x0.1 mg
- 保存建议：
- Store at -80 degree C
- 货期：
- 6-8周
- 纯度：
- >95%; Ion-exchange Purified
- 产品形式：
- PB pH 7.4, 5 mM EDTA, 50 mM DTT
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body (3). It works by catalyzing the dismutation of the superoxide radical O2? to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase (2,5). In general, SODs play a major role in antioxidant defense mechanisms (4). There are two main types of SOD in mammalian cells. One form (SOD1) contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cysteines forming an intra-subunit disulphide bridge (3). The second form (SOD2) is a manganese containing enzyme and resides in the mitochondrial matrix. It is a homotetramer of 80 kDa. The third form (SOD3 or EC-SOD) is like SOD1 in that it contains Cu and Zn ions, however it is distinct in that it is a homotetramer, with a mass of 30 kDA and it exists only in the extra-cellular space (7). SOD3 can also be distinguished by its heparin-binding capacity (1). Studies have shown that in vitro, Cu-Zn SOD (SOD1) fibrils are transduced into cells and function as seeds to trigger the aggregation of endogenously expressed SOD1 (9).
