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Human Recombinant Tau (K18) Delta K280 Mutant Protein Pre-formed Fibrils
Human Recombinant Tau (K18) Delta K280 Mutant Protein Pre-formed Fibrils
- 中文名称：
- Human Recombinant Tau (K18) Delta K280 Mutant Protein Pre-formed Fibrils
- 英文名称：
- Human Recombinant Tau (K18) Delta K280 Mutant Protein Pre-formed Fibrils
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA254097
- 规格：
- 0.1 mg|2x0.1 mg|5x0.1 mg
- 保存建议：
- Store at -80 degree C
- 货期：
- 6-8周
- 纯度：
- >95%; Ion-exchange Purified
- 产品形式：
- PBS pH 7.4
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Alzheimer's Disease (AD) is the most common neurodegenerative disease, affecting 10% of seniors over the age of 65 (1). It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing hyperphosphorylated tau fibrils (3). The deltaK280 mutation is associated with frontotemporal dementia and promotes fibrillization into paired helical filaments (PHFs) in the absence of heparin and other inducers (4). K18 is a truncated form of human tau containing only the 4 microtubule binding repeats (5).
