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Mouse HER3/ERBB3 HEK293 Overexpression Lysate
Mouse HER3/ERBB3 HEK293 Overexpression Lysate
- 中文名称：
- Mouse HER3/ERBB3 HEK293 Overexpression Lysate
- 英文名称：
- Mouse HER3/ERBB3 HEK293 Overexpression Lysate
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA257384
- 规格：
- 0.3 mg|2x0.3 mg|3x0.3 mg|4x0.3 mg|5x0.3 mg
- 保存建议：
- Store at 4 degree C for up to twelve months from date of receipt. After re-dissolution, aliquot and store at -80 degree C for up to twelve months. Avoid repeated freeze-thaw cycles.
Samples are stable for up to twelve months from date of receipt.
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- 1x Sample Buffer (1x modified RIPA buffer+1x SDS loading buffer).
Modified RIPA Lysis Buffer: 50 mM Tris-HCl pH 7.4, 150 mM NaCl, 1mM EDTA, 1% Triton X-100, 0.1% SDS, 1% Sodium deoxycholate, 1mM PMSF.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.
This Mouse HER3/ERBB3 overexpression lysate was created in HEK293 Cells and intented for use as a Western blot (WB) positive control. Purification of HER3/ERBB3 protein from the overexpression lysate was verified.
