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ITPRIPL1 Protein, Human, Recombinant (ECD, His Tag), HPLC-verified
ITPRIPL1 Protein, Human, Recombinant (ECD, His Tag), HPLC-verified
- 中文名称：
- ITPRIPL1 Protein, Human, Recombinant (ECD, His Tag), HPLC-verified
- 英文名称：
- ITPRIPL1 Protein, Human, Recombinant (ECD, His Tag), HPLC-verified
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA259194
- 规格：
- 0.1 mg|1 mg|2x1 mg|3x1 mg|4x1 mg
- 保存建议：
- Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
- 货期：
- 6-8周
- 纯度：
- >= 95% as determined by SDS-PAGE.
= 90% as determined by SEC-HPLC.
- 产品形式：
- Lyophilized from sterile PBS, pH 7.4.
Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Inositol 1,4,5-trisphosphate Receptor Interacting Protein-Like 1 or ITPRIPL1 is a transmembrane protein with broad expression in the testis associated with immune evasion. In fact, ITPRIPL1 is a molecule specifically expressed in immune privileged tissues, "hot" tumors without PD-L1 expression, and non-responding tumors to PD-1 blockade therapy. ITPRIPL1 has been shown to impair T cell function in vitro and in vivo through CD3e with experimental evidence supporting a negative correlation between ITPRIPL1 expression level in antigen-presenting cells and T cell cytotoxicity. ITPRIPL1 was a hypermethylated-low expression gene in breast cancer and acted as an independent biomarker for the prognosis of lung adenocarcinoma by using bioinformatics methods. Thus, targeting the ITPRIPL1-CD3e axis, especially in PD-1-PD-L1 negative patients, is a promising therapeutic strategy to reduce immune evasion.
