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Recombinant Human SIGLEC8 Protein (ECD, His Tag), HPLC-verified
Recombinant Human SIGLEC8 Protein (ECD, His Tag), HPLC-verified
- 中文名称：
- Recombinant Human SIGLEC8 Protein (ECD, His Tag), HPLC-verified
- 英文名称：
- Recombinant Human SIGLEC8 Protein (ECD, His Tag), HPLC-verified
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA259205
- 规格：
- 0.1 mg|1 mg|2x1 mg|3x1 mg|4x1 mg
- 保存建议：
- Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
- 货期：
- 6-8周
- 纯度：
- >= 95% as determined by SDS-PAGE.
= 90% as determined by SEC-HPLC.
- 产品形式：
- Lyophilized from sterile 20mM MES, 150mM Nacl, 10% Glycerol, 10% Trehalose, pH 6.0.
Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Siglec-8, also known as SAF2, is a single-pass transmembrane CD33 subfamily receptor selectively expressed on human eosinophils and mast cells. Capable of exhibiting cell-type dependent inhibitory activity, siglec-8 has a N-terminal V-set Ig domain containing a sialoglycan binding site that forms strong interactions with the carboxylate group in sialic acid for ligation. In its cytoplasmic domain, siglec-8 has an immunoreceptor tyrosine-based inhibitory motif (ITIM) thought to be critical for downstream signaling and function. Engagement of Siglec-8 on cytokine-primed eosinophils promotes cell death through generation of reactive oxygen species. In contrast, siglec-8 engagement on mast cells inhibits cellular activation and mediator release. Siglec-8 agonist antibodies are currently under investigation for treatment of allergic and inflammatory diseases involving mast cells and eosinophils
