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Recombinant Human LY6G6D Protein (hFc Tag)
Recombinant Human LY6G6D Protein (hFc Tag)
- 中文名称：
- Recombinant Human LY6G6D Protein (hFc Tag)
- 英文名称：
- Recombinant Human LY6G6D Protein (hFc Tag)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA259207
- 规格：
- 0.1 mg|1 mg|2x1 mg|3x1 mg|4x1 mg
- 保存建议：
- 请按照说明书指示
- 货期：
- 6-8周
- 纯度：
- >= 90% as determined by SDS-PAGE.
- 产品形式：
- Lyophilized from sterile PBS, pH 7.4.
Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
The Lymphocyte Antigen 6 Family Member G6D (LY6G6D) is a member of the LY6 family of proteins (typically 70-80 amino acids), mostly GPI-anchored to the cell surface. Regulated by the JAK-STAT5 and RAS-MEK-ERK cascades and belonging to a cluster of leukocyte antigens located in the MHC III region on chromosome 6, LY6G6D demonstrates selective expression in colorectal cancer (CRC), particularly the microsatellite stable subtype, with minimal to no expression in normal tissues. LY6G6D expression is also enhanced in diseases characterized by systemic immune suppression, such as autosomic dominant monocytopenia. LY6G6D up-regulation was predominant in CRCs characterized by an enrichment of immune suppressive regulatory T-cells and limited PD-1/PD-L1 immune checkpoint receptors, demonstrating its potential as a target for novel T-cell-dependent bispecific antibodies that can redirect T-cell effector function to colorectal tumors.
