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Recombinant Mouse MADCAM1 Protein (ECD, His Tag), HPLC-verified
Recombinant Mouse MADCAM1 Protein (ECD, His Tag), HPLC-verified
- 中文名称：
- Recombinant Mouse MADCAM1 Protein (ECD, His Tag), HPLC-verified
- 英文名称：
- Recombinant Mouse MADCAM1 Protein (ECD, His Tag), HPLC-verified
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA259268
- 规格：
- 0.1 mg|1 mg|2x1 mg|3x1 mg|4x1 mg
- 保存建议：
- Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
- 货期：
- 6-8周
- 纯度：
- >= 95% as determined by SDS-PAGE.
= 90% as determined by SEC-HPLC.
- 产品形式：
- Lyophilized from sterile PBS, pH 7.4.
Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Mucosal addressin cell adhesion molecule-1 (MAdCAM-1), an immunoglobulin, is a membrane-bound receptor expressed on high endothelial venules, promoting the migration of immune cells from the bloodstream to gut-associated mucosal tissues via interaction with alpha4beta7 integrin. Beginning from its N terminus, two IgSF domains, a mucin-like region, a transmembrane domain, and a 43-residue cytoplasmic domain define the structure of MAdCAM-1. While expression of MAdCAM-1 is upregulated under acute and chronic inflammatory conditions like in inflammatory bowel disease, its deficiency resulted in decreased production of ConA-induced proinflammatory mediators. In a promising cancer study, an anti-MAdCAM-1 antibody reduced the number of migrating CD8+, CD68+ and CD163+ immune cells and suppressed IL-6/p-STAT3 and TNF-alpha/NF-kappaB pathway expression in mice, thus reducing colon carcinogenesis and tumor aggressiveness.
