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Recombinant Human DPP3 Protein (His Tag), HPLC-verified
Recombinant Human DPP3 Protein (His Tag), HPLC-verified
- 中文名称：
- Recombinant Human DPP3 Protein (His Tag), HPLC-verified
- 英文名称：
- Recombinant Human DPP3 Protein (His Tag), HPLC-verified
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA259287
- 规格：
- 0.1 mg|1 mg|2x1 mg|3x1 mg|4x1 mg
- 保存建议：
- Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Liquid. It is shipped out with blue ice.
- 货期：
- 6-8周
- 纯度：
- >= 95% as determined by SDS-PAGE. >= 95% as determined by SEC-HPLC.
- 产品形式：
- Supplied as sterile 50mM Tris, 150mM NaCl, 10% Glycerol, 0.02% (w/v) Brij-35, pH 9.0.Please contact us for any concerns or special requirements.Please refer to the specific buffer information in the hardcopy of datasheet.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Dipeptidyl peptidase 3 (DPP3) is a zinc-dependent peptidase distributed within the cytoplasm which cleaves dipeptides sequentially from the N-terminus of bioactive peptide substrates 4+ amino acid residues in length. DPP3 adopts a bi-lobed structure and features HEXXGH and EEXRAE/D motifs which coordinate the Zn2+ion in its active site. DPP3's gene is located on chromosome 11q12-13.113. DPP3 regulates the transformation of enkephalin, opioid peptide, terminal protein, and cell signaling. Deficiency results in ROS formation in the kidneys via elevated Angiotensin II (DPP3's most prominent reported substrate), III, IV, and ANG (1-5). DPP3 is linked to the development of cardiovascular diseases through RAS, oxidative stress, and inflammation pathways. Depletion was associated with the upregulation of proapoptotic proteins SMAC and p53, making it a potential target in tumor therapy.
