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Recombinant 2019-nCoV S Protein RBD (C-mFc) (Mammalian expression)
Recombinant 2019-nCoV S Protein RBD (C-mFc) (Mammalian expression)
- 中文名称：
- Recombinant 2019-nCoV S Protein RBD (C-mFc) (Mammalian expression)
- 英文名称：
- Recombinant 2019-nCoV S Protein RBD (C-mFc) (Mammalian expression)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA268899
- 规格：
- 0.05 mg|2x0.05 mg|3x0.05 mg|4x0.05 mg|5x0.05 mg
- 保存建议：
- Ships on dry ice. Reconstituted protein solution should be stored at <= -20 degree C.
- 货期：
- 6-8周
- 纯度：
- >95% as determined by reducing SDS-PAGE. Affinity purification chromatography
- 产品形式：
- Supplied as a 0.2um filtered solution of PBS, pH 7.4
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Description: Recombinant 2019-nCoV S1 Protein is produced by our Mammalianexpression system and the target gene encoding Gln14-Arg685 is expressed with a mFctag at the C-terminus.
Background: Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement inmultiple biological processes that include coagulation, apoptosis, cancer development and progression, and theinnate immune response. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, CEACAMetc. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
