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Recombinant Human IFN-alpha 4 Protein
Recombinant Human IFN-alpha 4 Protein
- 中文名称：
- Recombinant Human IFN-alpha 4 Protein
- 英文名称：
- Recombinant Human IFN-alpha 4 Protein
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA283368
- 规格：
- 0.02 mg|0.05 mg|0.1 mg|2x0.1 mg|3x0.1 mg
- 保存建议：
- Store at -20 degree C. Store the lyophilized protein at -20 degree C to -80 degree C up to 1 year from the date of receipt.
After reconstitution, the protein solution is stable at -20 degree C for 3 months, at 2-8 degree C for up to 1 week.
- 货期：
- 6-8周
- 纯度：
- >90% by SDS-PAGE.
- 产品形式：
- Lyophilized from 0.22 um filtered solution in PBS (pH7.4). Normally 8% trehalose is added as protectant before lyophilization.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
IFN-alpha 4, Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.The interferons (IFN) are a family of cytokines with potent antiviral, antiproliferative and immunomodulatory properties, and are classified based on their binding specificity to cell surface receptors. The type I IFNs bind to the interferon alpha receptor (IFNAR), which consists of two subunits: IFNAR1 (alpha -subunit) and IFNAR2 (beta -subunit). This binding contributes to TNF-alpha induced signaling. Both the human and mouse genome code for more than a dozen closely related IFN-alpha subtypes and the various IFN-alphas share about 80% sequence homology among them. The mouse IFN-alpha 4 consists of 186 amino acids (aa) including a 24 aa signal peptide and a 162 aa IFN-alpha 4 mature domain. The mature mouse IFN-alpha 4 shares 58% and 76% sequence identity with mature human and rat IFN-alpha 4, respectively. The mouse IFN-alpha 4 reduces the local replication of murine cytomegalovirus in the tibia muscle. mIFN-A4 is a strong activator of Mx gene and was shown to be very effective in reducing splenomegaly.
