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Recombinant Human Troponin I Type 2
Recombinant Human Troponin I Type 2
- 中文名称：
- Recombinant Human Troponin I Type 2
- 英文名称：
- Recombinant Human Troponin I Type 2
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA38441
- 规格：
- 0.002 mg|0.01 mg|1 mg|2x1 mg|3x1 mg
- 保存建议：
- TNNI2 Human although stable at 10 degree C for 7 days, should be stored below -18 degree C.Please prevent freeze-thaw cycles.
- 货期：
- 6-8周
- 纯度：
- Greater than 85.0% as determined by SDS-PAGE.
- 产品形式：
- The protein solution contains 20mM Tris-HCl, 500mM NaCl and 10mM b-ME, pH 7.5.
Sterile Filtered colourless liquid formualtion.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Description: Skeletal isoforms of Troponin I were suggested to be used as markers of acute and chronic skeletal muscle injuries. In skeletal muscles Troponin I is presented by two forms, slow (21.6 kDa) and fast (21.2 kDa) skeletal. The protein (Fast Skeletal Troponin I) migrates on SDS-PAGE to approximately 26.5kDa.
Introduction: TNNI2 is a fast-twitch skeletal muscle protein, belongs to the troponin I gene family, and is part of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, together with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. TNNI2 is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. Other than muscle tissues, TNNI2 is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a coactivator of estrogen receptor-related receptor alpha. Furthermore, TNNI2 suppresses tumor growth in human ovarian carcinoma. Mutations in the TNNI2 gene cause myopathy and distal arthrogryposis type 2B.
