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Recombinant Human High-Mobility Group Box 1 Hi-5 Insect Cells
Recombinant Human High-Mobility Group Box 1 Hi-5 Insect Cells
- 中文名称：
- Recombinant Human High-Mobility Group Box 1 Hi-5 Insect Cells
- 英文名称：
- Recombinant Human High-Mobility Group Box 1 Hi-5 Insect Cells
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA38632
- 规格：
- 0.005 mg|0.02 mg|1 mg|2x1 mg|3x1 mg
- 保存建议：
- 请按照说明书指示
- 货期：
- 6-8周
- 纯度：
- Greater than 90% as determined by SDS-PAGE.
- 产品形式：
- The HMG1 solution (1mg/ml) contains 20mM Tris-HCl pH-8, 1mM EDTA, 0.5mM DTT and 10% glycerol.
Sterile Filtered colorless solution.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Description: HMG1 Human Recombinant fused to an 8 aa His-Tag at C-terminus produced in High Five insect cells is a single, glycosylated, polypeptide chain (amino acids 1-215) containing 223 amino acids and having a molecular mass of 25 kDa.The HMGB1 is purified by proprietary chromatographic techniques.
Introduction: HMGB1 is an abundant chromatin-binding protein found in eukaryotic cell nucleus and acts in the assembly of nucleoprotein complexes. Inside the cell, HMGB1 binds to DNA and is involved in transcriptional regulation. Outside the cell, HMGB1 acts as a cytokine with activities that resemble those of tumor necrosis factor (TNF). HMGB1 is elevated significantly in chronic kidney disease patients and correlates with glomerular filtration rate as well as with markers of inflammation and malnutrition. HMGB1 is involved in Gram-negative sepsis by catalyzing movement of LPS monomers from LPS aggregates to CD14 to initiate a TLR4-mediated proinflammatory response. HMGB1 plays an important role in the relationship between necrosis and malignancy in glioma tumours. HMG1 protein is induced by Mycobacterium bovis BCG. Overexpression of HMGB1 is common in gastrointestinal stromal tumors and is related to the KIT mutation. HMG1 induces growth inhibition and apoptosis in macrophages through RAGE intracellular signaling pathway. The increase of extracellular HMGB1 observed in salivary glands of Sjogren's syndrome patients indicates that HMGB-1 is involved in the inflammatory process of the disease. HMGB-1 together with estrogen increase cell cycle progression in tumor cell lines.
