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Recombinant Human Integrin Linked Kinase
Recombinant Human Integrin Linked Kinase
- 中文名称：
- Recombinant Human Integrin Linked Kinase
- 英文名称：
- Recombinant Human Integrin Linked Kinase
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA38689
- 规格：
- 0.002 mg|0.01 mg|1 mg|2x1 mg|3x1 mg
- 保存建议：
- Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. Please avoid freeze thaw cycles.
- 货期：
- 6-8周
- 纯度：
- Greater than 95.0% as determined by SDS-PAGE.
- 产品形式：
- ILK1 protein is supplied in 25mM Sodium Acetate (pH 4.8) and 50% glycerol.
Sterile Filtered clear solution.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Description: ILK1 Human Recombinant produced in E Coli is single, a non-glycosylated, Polypeptide chain containing 452 amino acids fragment (1-452) having a molecular mass of 55.92kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. The ILK1 is purified by proprietary chromatographic techniques.
Introduction: ILK1 (Integrin-linked kinase) is a serine/threonine protein kinase, containing 4 ankyrin-like repeats. ILK1 regulates a number of biological properties which include: anchorage-independent cell cycle progression, tumor cell invasion and apoptosis. ILK1 can also be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Furthermore, ILK1 phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.ILK1 interacts with the cytoplasmic domains of integrin ?1 and ?3 subunits in addition to several adaptors and signaling proteins, it also acts as a proximal receptor kinase regulating integrin-mediated signal transduction. ILK1 is a focal adhesion protein part of the complex ILK-PINCH. This complex is deemed to be one of the convergence points of integrin- and growth factor-signaling pathway. ILK1 is stimulated rapidly but briefly by both cell fibronectin interactions, as well as by insulin, in a PI3-K-dependent manner, probably through the binding of PtdIns(3,4,5)P3 with a PH-like domain of ILK.ILK1 over-expression has been documented in a wide variety of human malignancies.
