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Recombinant Human Insulin Like Growth Factor Binding Protein-7
Recombinant Human Insulin Like Growth Factor Binding Protein-7
- 中文名称：
- Recombinant Human Insulin Like Growth Factor Binding Protein-7
- 英文名称：
- Recombinant Human Insulin Like Growth Factor Binding Protein-7
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA39127
- 规格：
- 0.005 mg|0.025 mg|1 mg|2x1 mg|3x1 mg
- 保存建议：
- Lyophilized IGFBP7 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IGFBP-7 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein (0.1 HSA or BSA).
Please prevent freeze-thaw cycles.
- 货期：
- 6-8周
- 纯度：
- Greater than 97.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
- 产品形式：
- The IGFBP7 was lyophilized from a 0.2 um filtered concentrated solution in 20mM Tris-HCl, pH 8.5 and 150mM NaCl.
Sterile Filtered White lyophilized (freeze-dried) powder.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Description: Recombinant Human IGFBP7 produced in E Coli cells is a non-glycosylated, homodimeric protein containing 2 x 256 amino acid chains and having a molecular mass of 26.4kDa. The IGFBP-7 is purified by proprietary chromatographic techniques.
Introduction: Insulin-like Growth Factor-Binding Protein 7 (IGFBP7) is a member of the IGFBP family. IGFBP family members are all cysteine rich proteins with conserved cysteine and have an IGFBP domain, a Kazal-like domain and an Ig-like C2-type domain. IGFBP7 is expressed in a broad range of normal human tissues and it mostly shows reduced expression in cancer cell lines of prostate, breast, colon, and lung origin. IGFBP7 has a role in skeletal myogenesis by binding to IGF in a manner which inhibits IGF induced differentiation of skeletal myoblasts, without disturbing IGF induced proliferation. Moreover, IGFBP7 suppresses growth and colony formation of prostate and breast cancer cell lines via an IGF independent mechanism, which triggers a delay in the G1 phase of the cell cycle, and increased apoptosis.
