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Integrin alpha 4 Recombinant Protein
Integrin alpha 4 Recombinant Protein
- 中文名称：
- Integrin alpha 4 Recombinant Protein
- 英文名称：
- Integrin alpha 4 Recombinant Protein
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA40474
- 规格：
- 0.05 mg|2x0.05 mg|3x0.05 mg|4x0.05 mg|5x0.05 mg
- 保存建议：
- Store in working aliquots at -70 degree C. Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
Shipping: Dry Ice.
- 货期：
- 6-8周
- 纯度：
- ~95%
- 产品形式：
- Liquid
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
The integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha and beta chains (reviewed in 1). Alpha 4(4) chain associates with either beta 1(1) or beta 7 7) chain. It has been demonstrated that the putative ligand-binding sites of both integrin 41 and 47 is located on the 4 chain. These ligands included Madcam, VCAM, and fibronectin (2-4). Madcam is known as the principal ligand for integrin a4b7. Recently it was also demonstrated that HIV-1 envelope can mimic Madcam by binding to and signaling though integrin 47, the gut mucosal homing receptor for peripheral T cells 5). This recombinant protein fragment includes the ligand and monoclonal antibody binding domains; this binding has been tested and verified in ELISA assays. This recombinant protein is recognized PSI antibodies Integrin 4(IN1) PSI 4827) and Integrin 4(IN2)(PSI 4837), but not Integrin 4(CT)(PSI 4783).
