![SARS-CoV-2 (COVID-19) Spike S2 Single Domain Antibody [P1B8]](/skin/notimg.webp)
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SARS-CoV-2 (COVID-19) Spike S2 Single Domain Antibody [P1B8]
SARS-CoV-2 (COVID-19) Spike S2 Single Domain Antibody [P1B8]
- 中文名称：
- SARS-CoV-2 (COVID-19) Spike S2 Single Domain Antibody [P1B8]
- 英文名称：
- SARS-CoV-2 (COVID-19) Spike S2 Single Domain Antibody [P1B8]
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA40985
- 规格：
- 0.1 mg|2x0.1 mg|3x0.1 mg|4x0.1 mg|5x0.1 mg
- 保存建议：
- SARS-CoV-2 (COVID-19) Spike S2 Antibody should be stored in working aliquots at -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- 货期：
- 6-8周
- 纯度：
- SARS-CoV-2 (COVID-19) Spike S2 Antibody is affinity chromatography purified via Nickel column. Antibody is supplied as a His-tagged purified protein. It also contains a myc-tag for detection.
- 产品形式：
- Liquid; SARS-CoV-2 (COVID-19) Spike S2 Antibody is supplied in PBS.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
As SARS-CoV-2 Spike S2 protein is more conserved among coronaviruses than Spike S1 protein, antibodies against spike S2 protein may react with more Coronaviruses, serving as a pan-coronvirus antibody. The functional characteristics analysis revealed that P1B8 has excellent binding activity to SARS-CoV-2 variants (delta and omicron), but weaker binding activity to SARS-CoV-1. Biotinylated P1B8 can still bind spike trimer of SARS-CoV-2. In addition, P1B8 and another three spike S2 sdAbs (P1G5, P1A9, and P1A6) belong to different families based on their sequence alignment, and epitope mapping experiment indicated that they may bind to different epitopes with different affinity to the different strains in the binding ELISA. Our data showed that these spike S2 sdAbs bind spike trimer of both SARS-CoV-2 and SARS-CoV-1, suggesting that these spike S2 sdAbs have potentials as a novel and efficient tool suitable for pan-coronavirus studies as well as for identification of various coronaviruses and their variants from clinical samples.
