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Recombinant SARS-CoV-2 (2019-nCoV) S1 Protein
Recombinant SARS-CoV-2 (2019-nCoV) S1 Protein
- 中文名称：
- Recombinant SARS-CoV-2 (2019-nCoV) S1 Protein
- 英文名称：
- Recombinant SARS-CoV-2 (2019-nCoV) S1 Protein
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA41021
- 规格：
- INQUIRE
- 保存建议：
- Ships on blue ice. Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 degree C for one week .
Store at -20 to -80 degree C for twelve months from the date of receipt.
- 货期：
- 6-8周
- 纯度：
- >90% as determined by SDS-PAGE quantitative densitometry by Coomassie Blue staining.
- 产品形式：
- Lyophilized. Lyophilized from PBS, pH7.5, 0.02% NLS, 5% Trehalose, 5% Mannose, 1mM EDTA.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Recombinant SARS-CoV-2 S1 Protein is produced by E.coli expression system and the target gene encoding Val16-Gln677 is expressed with N-His Tag
Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, CEACAM etc.. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
