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pLenti-AAVR-Puro Vector
pLenti-AAVR-Puro Vector
- 中文名称：
- pLenti-AAVR-Puro Vector
- 英文名称：
- pLenti-AAVR-Puro Vector
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA44710
- 规格：
- 0.01 mg|2x0.01 mg|3x0.01 mg|4x0.01 mg|5x0.01 mg
- 保存建议：
- 储存在-20摄氏度
- 货期：
- 6-8周
- 纯度：
- N/A
- 产品形式：
- N/A
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Adeno-associated viruses (AAVs) are derived from defective parvoviruses, which depend on essential helper functions provided by other viruses, such as adenovirus and herpes virus, for efficient viral replication and propagation. AAV has no etiologic association with any known diseases and has been successfully used to establish efficient and long-term gene expression in vivo in a variety of tissues without significant cellular immune responses or toxicity. AAV has a single-stranded DNA genome which consists of approximately 4.7 kb. All characterized AAV serotypes share three key features, including two copies of AAV terminal repeats (ITRs), one rep region and one cap region. Recently, through genome-wide screening for genes essential to AAV transduction, type I transmembrane protein, KIAA0319L (renamed as AAV receptor (AAVR)) was implicated as the key receptor for entry of a panel of AAV serotypes into representative cell types and, in vivo, in mice (Ref. 4). AAVR has a single transmembrane region and a short C-terminal cytoplasmic domain required for retrograde trafficking to the trans-Golgi network. Its ectodomain, which binds AAV’s capsid, comprises five tandem Ig-like PKD (polycystic kidney disease) domains, a MANEC domain, and an N-terminal signal peptide (Figure 1).
