-
Recombinant Human Secretory Phospholipase A2 Receptor 1, PLA2R1
Recombinant Human Secretory Phospholipase A2 Receptor 1, PLA2R1
- 中文名称：
- Recombinant Human Secretory Phospholipase A2 Receptor 1, PLA2R1
- 英文名称：
- Recombinant Human Secretory Phospholipase A2 Receptor 1, PLA2R1
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA47141
- 规格：
- 0.01 mg|0.05 mg|0.1 mg|2x0.1 mg|3x0.1 mg
- 保存建议：
- The protein should be stored at -20°C to -70°C preferably in small aliquots to avoid repeated freeze-thaw cycles. It can be stored at 2°C to 8°C for 1 Month.
- 货期：
- 6-8周
- 纯度：
- Grade & Purity: >95% as estimated by SDS-PAGE stained with Instant Blue Stain (Expedeon)
- 产品形式：
- PBS 20% Glycerol
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
PLA2R is a type I transmembrane glycoprotein of 180-200 kDa and is present in a widevariety of cells and tissues (1). Receptor for secretory phospholipase A2 (sPLA2) belongingto the mannose receptor family (2). It is composed of a large extracellular N-terminalportion, consisting of a N-terminal cystein-rich region, a fibronectin-like type II domain, atandem repeat of eight carbohydrate-recognition domains essential for ligand binding, and short intracellular C-terminal region. Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B. Also able to bind to snake PA2-like toxins. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogenactivated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipidmediators, selective release of arachidonic acid in bone marrow-derived mast cells. Inneutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock (3). The soluble secretory phospholipase A2 receptorform is circulating and acts as a negative regulator of sPLA2 functions by blocking thebiological functions of sPLA2-IB/PLA2G1B.
PLA2R is expressed on the surface of podocytes and represents a target autoantigen in 70% of patients with idiopathic membranous nephropathy (4). It has a test value indetecting and quantifying anti-PLA2R auto immunity.
