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Recombinant SARS-CoV-2 Spike protein, P.1. variant of concern (Brazilian variant, L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I and V1176F)
Recombinant SARS-CoV-2 Spike protein, P.1. variant of concern (Brazilian variant, L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I and V1176F)
- 中文名称：
- Recombinant SARS-CoV-2 Spike protein, P.1. variant of concern (Brazilian variant, L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I and V1176F)
- 英文名称：
- Recombinant SARS-CoV-2 Spike protein, P.1. variant of concern (Brazilian variant, L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I and V1176F)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA47145
- 规格：
- 0.1 mg|2x0.1 mg|3x0.1 mg|5x0.1 mg|4x0.1 mg
- 保存建议：
- The protein can be stored at 2-8°C for 1 month. For long term, it should be stored at -20°C to -70°C preferably in small aliquots to avoid repeated freeze-thaw cycles.
- 货期：
- 6-8周
- 纯度：
- Affinity chromatography, >90% as estimated by SDS-PAGE
- 产品形式：
- Liquid; PBS 20% Glycerol
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Full-length soluble with foldon trimerization motif, mutated Furin recognition site and 6 stabilising mutations (F817P, A892P, A899P, A942P, K986P and V987P), based on/modified from Amanat et al, 2020 and Hsieh et al, 2020.
The first reports of atypical pneumonia in China were announced at the very end of 2019, in the city of Wuhan, Hubei province. Its cause was identified in January 2020 as a novel β-CoV (1), named SARS-CoV-2, which started spreading very quickly causing a global pandemic COVID-19. Spike protein attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (2, 3). The protein forms a trimer in vivo mediating receptor binding and membrane fusion (4). It has been demonstrated by Florian Krammer’s group that certain mutations and the inclusion of trimerization motif can stabilize recombinant Spike protein (5, 6). The original Wuhan strain of the virus has become quickly replaced by its more transmissible variant, mainly determined by a single amino acid point mutation D614G (7). A novel SARS-CoV-2 variant, P.1, known as Brazilian variant, originated in the Amazonas state of Brazil and started spreading quickly in adjacent countries as well as the USA (8,9).
上一篇：Recombinant SARS-CoV-2 Spike protein, Delta B.1.617.2 variant (Indian variant, T19R, G142D, EF156-157del, R158G, L452R, T478K, D614G, P681R and D950N)
下一篇：Recombinant SARS-CoV-2 Spike protein, Beta Variant of Concern, B.1.351 variant (South Africa, L18F, D80A, D215G, ?242-244, R246I, K417N, E484K, N501Y, D614G and A701V)
