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Recombinant Human HER3 protein with C-terminal 6xHis tag
Recombinant Human HER3 protein with C-terminal 6xHis tag
- 中文名称：
- Recombinant Human HER3 protein with C-terminal 6xHis tag
- 英文名称：
- Recombinant Human HER3 protein with C-terminal 6xHis tag
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA47244
- 规格：
- 0.01 mg|0.05 mg|0.1 mg|2x0.1 mg|3x0.1 mg
- 保存建议：
- Store at -80 degree C for 12 months (Avoid repeated freezing and thawing)
Shipping: Blue Ice
- 货期：
- 6-8周
- 纯度：
- The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
- 产品形式：
- Lyophilized from sterile PBS, pH 7.4. Normally 5%-74% trehalose is added as protectants before lyophilization.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.
