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Recombinant mouse IL-21 R protein
Recombinant mouse IL-21 R protein
- 中文名称：
- Recombinant mouse IL-21 R protein
- 英文名称：
- Recombinant mouse IL-21 R protein
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA48412
- 规格：
- 0.01 mg|0.02 mg|0.05 mg|0.1 mg|5x0.01 mg
- 保存建议：
- Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
- 货期：
- 6-8周
- 纯度：
- > 95% by SDS-PAGE
- 产品形式：
- Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
IL-21R (Interleukin 21 receptor), also known as NILR, belongs to the type I cytokine receptor family and Type 4 subfamily. This receptor is Heterodimer with the common gamma subunit and transduces the growth promoting signal of IL21. It is important for the proliferation and differentiation of T cells, B cells, and NK cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. B cell IL?21 R engagement induces Blimp-1, and is important for memory responses. It engagement on mouse NK cells enhances their cytotoxic activity and IFN-gamma production. It is selectively expressed in lymphoid tissues and most highly expressed in thymus and spleen and IL21 impacts some cell types, including CD8+ memory T cells, NK cells, and subsets of CD4 memory T cells. It is also necessary for sufficient numbers of regulatory T cells to combat chronic inflammation. Recombinant mouse IL21R, fused to hIgG-His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.
