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Recombinant human Fc gamma RIIIA/CD16a protein
Recombinant human Fc gamma RIIIA/CD16a protein
- 中文名称：
- Recombinant human Fc gamma RIIIA/CD16a protein
- 英文名称：
- Recombinant human Fc gamma RIIIA/CD16a protein
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA48425
- 规格：
- 0.01 mg|0.02 mg|0.05 mg|0.1 mg|5x0.01 mg
- 保存建议：
- Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
- 货期：
- 6-8周
- 纯度：
- > 95% by SDS-PAGE
- 产品形式：
- Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Fc gamma RIIIA/CD16a is also known as Low affinity immunoglobulin gamma Fc region receptor III-A isoform c. It is optimally activated upon binding of clustered antigen-IgG complexes displayed on cell surfaces, triggers lysis of antibody-coated cells, a process known as antibody-dependent cellular cytotoxicity (ADCC). Also mediates IgG effector functions on natural killer (NK) cells. Binds antigen-IgG complexes generated upon infection and triggers NK cell-dependent cytokine production and degranulation to limit viral load and propagation. Involved in the generation of memory-like adaptive NK cells capable to produce high amounts of IFNG and to efficiently eliminate virus-infected cells via ADCC. Regulates NK cell survival and proliferation, in particular by preventing NK cell progenitor apoptosis. Fc gamma RIIIA is mediates the antitumor activities of therapeutic antibodies. Upon ligation on monocytes triggers TNFA-dependent ADCC of IgG-coated tumor cells. Recombinant human Fc gamma RIIIA/CD16a, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.
