-
VHL protein (beta-domain), 1-154aa, Human, His tag, E Coli
VHL protein (beta-domain), 1-154aa, Human, His tag, E Coli
- 中文名称：
- VHL protein (beta-domain), 1-154aa, Human, His tag, E Coli
- 英文名称：
- VHL protein (beta-domain), 1-154aa, Human, His tag, E Coli
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA48466
- 规格：
- 0.02 mg|0.1 mg|0.5 mg|5x0.02 mg|5x0.1 mg
- 保存建议：
- Can be stored at 2-8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Avoid repeated freezing and thawing cycles.
- 货期：
- 6-8周
- 纯度：
- > 95% by SDS-PAGE
- 产品形式：
- Liquid. In phosphate-buffered saline (pH 7.4) containing 1mM DTT, 2mM EDTA
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Von Hippel-Lindau disease (VHL) is a dominant inherited syndrome characterized by the predisposition to develop various kinds of benign and malignant tumors, including clear cell renal carcinomas, pheochromocytomas and hemangioblastomas of the central nervous system and retina. VHL syndrome is caused by germline mutation in the VHL tumor suppressor, and VHL tumors are associated with loss or mutation of the remaining wild-type allele. VHL has two domains: a roughly 100-residue NH2-terminal domain rich in beta sheet (beta-domain) and a smaller alpha-helical domain (alpha-domain), held together by two linkers and a polar interface. VHL protein is also involved in the degradation of hypoxia-inducible factor (HIF). VHL beta-domain (1-154aa) was overexpressed in E Coli and purified by using conventional chromatography techniques
