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Ataxin 3, 1-370aa, Human, E Coli
Ataxin 3, 1-370aa, Human, E Coli
- 中文名称：
- Ataxin 3, 1-370aa, Human, E Coli
- 英文名称：
- Ataxin 3, 1-370aa, Human, E Coli
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA48544
- 规格：
- 0.01 mg|0.05 mg|5x0.01 mg|0.25 mg|5x0.05 mg
- 保存建议：
- Can be stored 2-8°C for 1 week. For long term storage aliquot and store at -20°C to -80°C. Avoid freeze thaw cycles.
- 货期：
- 6-8周
- 纯度：
- > 90% by SDS-PAGE
- 产品形式：
- Liquid. In 20 mM Tris-HCl Buffer (pH 7.5) containing 2mM DTT, 50mM NaCl, 10% glycerol.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Ataxin 3 is also known as Machado-Joseph disease protein 1. Machado-Joseph disease is one of several hereditary autosomal dominant neurodegenerative disorders. This protein contains trinucleotide CAG repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is the cause of Machado-Joseph disease. Ataxin 3 interacts with the major histone acetyltransferases cAMP-response-element binding protein (CREB)-binding protein, p300, and p300/CREB-binding protein-associated factor and inhibits transcription by these coactivators. Also, ataxin-3 is a proteasome-associated factor that mediates the degradation of ubiquitinated proteins. Recombinant human Ataxin-3 was expressed in E Coli and purified by using conventional chromatography.
