-
RAB32, 1-225aa, Human, His tag, E Coli
RAB32, 1-225aa, Human, His tag, E Coli
- 中文名称：
- RAB32, 1-225aa, Human, His tag, E Coli
- 英文名称：
- RAB32, 1-225aa, Human, His tag, E Coli
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA48758
- 规格：
- 0.02 mg|0.1 mg|5x0.02 mg|0.5 mg|5x0.1 mg
- 保存建议：
- Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
- 货期：
- 6-8周
- 纯度：
- > 90% by SDS-PAGE
- 产品形式：
- Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 5mM DTT, 50% glycerol, 200mM NaCl, 2mM EDTA
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
RAB32 belongs to the small GTPase superfamily. RAB32 modulates ER calcium handling and disrupts the specific enrichment of calnexin on the MAM (mitochondria-associated membrane), while not affecting the ER distribution of protein-disulfide isomerase and mitofusin-2. Also, RAB32 determines the targeting of PKA (cAMP-dependent protein kinase) to mitochondrial and ER membranes and through its overexpression or inactivation increases the phosphorylation of Bad and of Drp1. Through a combination of its functions as a PKA-anchoring protein and a regulator of MAM properties, the activity and expression level of RAB32 determine the speed of apoptosis onset. Recombinant human RAB32 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.
