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SOS1, 564-1049aa, Human, His-tag, Baculovirus
SOS1, 564-1049aa, Human, His-tag, Baculovirus
- 中文名称：
- SOS1, 564-1049aa, Human, His-tag, Baculovirus
- 英文名称：
- SOS1, 564-1049aa, Human, His-tag, Baculovirus
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA48972
- 规格：
- 0.004 mg|0.02 mg|5x0.004 mg|0.1 mg|5x0.02 mg
- 保存建议：
- Can be stored at +2 degree C to +8 degree C for 1 week. For long term storage, aliquot and store at -20 degree C to -80 degree C. Avoid repeated freezing and thawing cycles.
- 货期：
- 6-8周
- 纯度：
- > 95% by SDS-PAGE
- 产品形式：
- Liquid. In 20mM Tris-HCl (pH 7.5) containing 30% glycerol, 0.1M NaCl, 1mM DTT, 0.2mM MgCl2.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
SOS1, also known as son of sevenless homolog 1, is a Ras and Rac guanine nucleotide exchange factor. This protein is composed of several important domains. The CDC25 and REM domains provide the catalytic activity of SOS1 towards Ras and the histone fold DH/PH (Dbl homology and Pleckstrin homology) domains function, in tandem, to stimulate GTP/GDP exchange for Rac. Also, binding of GTP activates Ras proteins, and subsequent hydrolysis of the bound GTP to GDP and phosphate inactivates signaling by these proteins. GTP binding can be catalyzed by guanine nucleotide exchange factors for RAS, and GTP hydrolysis can be accelerated by GTPase-activating proteins (GAPs). Recombinant human SOS1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
