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Recombinant Human Histone-lysine N-methyltransferase EZH2 (EZH2) Protein
Recombinant Human Histone-lysine N-methyltransferase EZH2 (EZH2) Protein
- 中文名称：
- Recombinant Human Histone-lysine N-methyltransferase EZH2 (EZH2) Protein
- 英文名称：
- Recombinant Human Histone-lysine N-methyltransferase EZH2 (EZH2) Protein
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA55967
- 规格：
- 0.1 mg|0.5 mg|1 mg|2x1 mg|3x1 mg
- 保存建议：
- Short Term: Store at 2-8°C
Long Term: Aliquot and store at -20°C to -80°C, buffer containing 50% glycerol is recommended for reconstitution
Avoid repeated freeze-thaw cycles
- 货期：
- 6-8周
- 纯度：
- > 90% as determined by SDS-PAGE
Affinity purification
- 产品形式：
- Lyophilized powder.
The purified protein was resolved in PBS (58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4). The elution buffer contained 300 mM imidazole.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Enhancer of zeste homolog 2 (EZH2) is a histone-lysine N-methyltransferase enzyme (EC 2.1.1.43) encoded by EZH2 gene, that participates in DNA methylation and, ultimately, transcriptional repression. EZH2 catalyzes the addition of methyl groups to histone H3 at lysine 27, by using the cofactor S-adenosyl-L-methionine. Methylation activity of EZH2 facilitates heterochromatin formation thereby silences gene function. Remodeling of chromosomal heterochromatin by EZH2 is also required during cell mitosis. EZH2 is the catalytic subunit of the Polycomb repressive complex 2 (PRC2). EZH2's catalytic activity relies on its formation of a complex with at least two other PRC2 components, SUZ12 and EED. As a histone methyltransferase (HMTase), EZH2's primary function is to methylate Lys-27 on histone 3 (H3K27me) by transferring a methyl group from the cofactor S-adenosyl-L-methionine (SAM), although recent studies have indicated that it is also capable of methylating non-histone proteins. EZH2 is capable of mono-, di-, and tri-methylation of H3K27 and has been associated with a variety of biological functions, including transcriptional repression and activation, hematopoiesis, development, and cell differentiation.
