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Squamous cell carcinoma antigen, SCCA Protein (Active)
Squamous cell carcinoma antigen, SCCA Protein (Active)
- 中文名称：
- Squamous cell carcinoma antigen, SCCA Protein (Active)
- 英文名称：
- Squamous cell carcinoma antigen, SCCA Protein (Active)
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA59077
- 规格：
- 0.1 mg|2x0.1 mg|3x0.1 mg|4x0.1 mg|5x0.1 mg
- 保存建议：
- Ships on blue ice. Upon receipt, aliquot and store at -20 degree C or -80 degree C for long term.
Avoid repeated freeze and thaw cycles.
- 货期：
- 6-8周
- 纯度：
- >95% by SDS-PAGE
- 产品形式：
- Liquid; Each vial contains Tris-HCl (pH7.4 ± 0.2) with 0.02% NaN3.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Squamous cell carcinoma antigen (SCCA) is a member of the ovalbumin family of serine proteinase inhibitors (serpins). SCCA is detected in the superficial and intermediate layers of normal squamous epithelium, whereas the mRNA is detected in the basal and subbasal levels. A neutral form of the protein (SCCA1, or SERPINB3) is found in normal and some malignant squamous cells, whereas an acidic form (SCCA2, or SERPINB4) is detected exclusively in tumor cells and in the circulation of patients with squamous cell tumors. SCCA1 shares 92% amino acid identity with SCCA2. Thus, the appearance of the acidic fraction of SCCA is correlated with more aggressive tumors. Ray et al. (2005) proposed that IL-4- and IL-13-stimulated SCCA gene expression is mediated via STAT-1 and STAT-6 activation, and by suppressing the production, and most likely by interfering with the signaling of these cytokines, UG inhibits SCCA gene expression associated with airway inflammation in asthma.
