-
Recombinant NSD2 (MMSET) protein
Recombinant NSD2 (MMSET) protein
- 中文名称：
- Recombinant NSD2 (MMSET) protein
- 英文名称：
- Recombinant NSD2 (MMSET) protein
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA59692
- 规格：
- 0.02 mg|1 mg|2x1 mg|3x1 mg|4x1 mg
- 保存建议：
- Recombinant proteins in solution are temperature sensitive and must be stored at -80 degree C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Shipping Temp: Dry Ice
- 货期：
- 6-8周
- 纯度：
- The recombinant protein is >= 75% pure by SDS-PAGE.
- 产品形式：
- Recombinant NSD2 (MMSET) protein is supplied at a concentration of 0.3ug/ul in 25mM HEPES-NaOH pH7.5, 500mM NaCl, 5% glycerol, 0.04% Triton X-100, 0.2mM TCEP.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Short Description: Recombinant MMSET/WHSC1 (accession number NP_579877.1) was expressed in Sf9 cells and contains an N-terminal DYKDDDDK tag with an observed molecular weight of 154 kDa. MMSET (Multiple Myeloma SET domain-containing protein)/WHSC1 (Wolf-Hirschhorn Syndrome Candidate 1; also known as NSD2, Nuclear Receptor binding SET domain protein 2; TRX5, Trithorax 5) is a SET domain-containing histone methyltransferase specific for lysine 36 of histone H3. The MMSET/WHSC1 gene is deleted in Wolf-Hirschhorn syndrome, a disorder characterized by developmental defects and mental retardation. In 15% of patients with Multiple Myeloma (MM), a chromosomal translocation leads to MMSET/WHSC1 gene being aberrantly placed under the control of the IgH intronic enhancer and expressed at very high levels. This event is apparently a key component in cellular transformation leading to MM. Reduction in MMSET/WHSC1 expression in a myeloma cell line suppressed its growth, suggesting a role for MMSET in maintaining the transformed state. Recombinant MMSET/WHSC1 protein can be used for enzyme kinetics and inhibitor screening studies.
Background: NSD2 (MMSET)(Multiple Myeloma SET domain-containing protein)/WHSC1 (Wolf-Hirschhorn Syndrome Candidate 1; also known as NSD2, Nuclear Receptor binding SET domain protein 2; TRX5, Trithorax 5) is a SET domain-containing histone methyltransferase specific for lysine 36 of histone H3. The NSD2 (MMSET) gene is deleted in Wolf-Hirschhorn syndrome, a disorder characterized by developmental defects and mental retardation. In 15% of patients with Multiple Myeloma (MM), a chromosomal translocation leads to NSD2 (MMSET) gene being aberrantly placed under the control of the IgH intronic u enhancer and expressed at very high levels. This event is apparently a key component in cellular transformation leading to MM. Reduction in NSD2 (MMSET) expression in a myeloma cell line suppressed its growth, suggesting a role for NSD2 (MMSET) in maintaining the transformed state.
