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Recombinant KDM2A/FBXL11 protein
Recombinant KDM2A/FBXL11 protein
- 中文名称：
- Recombinant KDM2A/FBXL11 protein
- 英文名称：
- Recombinant KDM2A/FBXL11 protein
- 品牌：
- AAA Biotech
- 品牌介绍：
- AAA Biotech专注于为全球生命科学研究提供高品质的蛋白质研究工具，核心产品包括经严格验证的抗体、重组蛋白及ELISA试剂盒。
- 货号：
- AAA59713
- 规格：
- 0.02 mg|1 mg|2x1 mg|3x1 mg|4x1 mg
- 保存建议：
- Ships on Dry Ice
Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
- 货期：
- 6-8周
- 纯度：
- The recombinant protein is >75% pure by SDS-PAGE.
- 产品形式：
- Full length recombinant FBXL11/KDM2A protein was expressed in Sf9 cells and is supplied in 25mM HEPES pH7.5, 500mM NaCl, 10% glycerol, and 0.5mM TCEP.
- 免责声明：
- *本产品仅供科研实验使用，不得用于临床诊断。*
- 说明书：
Short Description: Recombinant KDM2A/FBXL11 (accession number NP_036440.1) was expressed in Sf9 and contains an N-terminal DYKDDDDK-Tag with a molecular weight of 128 kDa. The recombinant protein is >75% pure by SDS-PAGE. It is suitable for use in the study of enzyme kinetics, inhibitor screening, and selectivity profiling.
Background: Lysine (K)-specific demethylase 2A (KDM2A), also known as FBXL11, JHDM1A, CXXC8, nucleates at CpG islands and specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis.
